HOXA9 Recruitment of Methyltransferase Complexes Alters Enhancer Landscape during Leukemic Transformation
نویسندگان
چکیده
منابع مشابه
Leukemic transformation of hematopietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
210 words. Total Text: 3, 686 words. Blood First Edition Paper, prepublished online December 30, 2003; DOI 10.1182/blood-2003-10-3722 Copyright (c) 2003 American Society of Hematology For personal use only. on November 16, 2017. by guest www.bloodjournal.org From
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Differential expression of Hox genes is associated with normal hematopoiesis, whereas inappropriate maintenance of Hox gene expression, particularly Hoxa7 and Hoxa9, is a feature of leukemias harboring mixed-lineage leukemia (MLL) mutations. To understand the pathogenic roles of Hox genes in MLL leukemias, we assessed the impact of Hoxa7 or Hoxa9 nullizygosity on hematopoietic progenitor compar...
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ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v130.suppl_1.783.783